Case Report

Multiple papular lesions in a patient with HIV and/or AIDS and coinfected with hepatitis B virus: Amyloidosis

Hayati Demiraslan, Kemal Deniz, Mehmet Doganay
Southern African Journal of HIV Medicine | Vol 18, No 1 | a735 | DOI: https://doi.org/10.4102/sajhivmed.v18i1.735 | © 2017 Hayati Demiraslan, Kemal Deniz, Mehmet Doganay | This work is licensed under CC Attribution 4.0
Submitted: 01 February 2017 | Published: 30 August 2017

About the author(s)

Hayati Demiraslan, Department of Infectious Diseases and Clinical Microbiology, Erciyes University, Turkey
Kemal Deniz, Department of Pathology, Erciyes University, Turkey
Mehmet Doganay, Department of Infectious Diseases and Clinical Microbiology, Erciyes University, Turkey

Abstract

Introduction: The most common form of systemic amyloidosis is amyloid A induced by a chronic inflammation. In HIV-infected patients, elevated serum amyloid A levels might be associated with chronic inflammation.

Patient presentation: A 43-year-old male patient was admitted to hospital with a complaint of papular lesions around his eyes, existing for four months. The patient is receiving antiretroviral therapy. HIV RNA was undetectable, and the CD4 count was 770 cells/mm3. He suffered from a bladder carcinoma for four years. On examination, periocular, perioral and anogenital papules, papular lesions in the meatus of external auditory canal, and intranasal polyps were observed.

Management: Microscopic examination of the biopsy material taken from the periocular lesion and then from perianal polyps revealed eosinophilic deposition, and stained positively by Congo red. Serum amyloid A level was negative. Antiretroviral therapy was continued.

Conclusion: A rare form of amyloidosis in a patient with HIV and/or AIDS and coinfected with hepatitis B virus (HBV) was presented here with cutaneous and mucosal lesions.


Keywords

Periocular papules; HIV/AIDS; amyloidosis; proteinuria

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