Case Report

Cavitation of the Ghon focus in an HIV-infected infant who acquired tuberculosis after the initiation of HAART

S. Innes, H. S. Schaaf, M. F. Cotton
Southern African Journal of HIV Medicine | Vol 10, No 1 | a1001 | DOI: https://doi.org/10.4102/sajhivmed.v10i1.1001 | © 2019 S. Innes, H. S. Schaaf, M. F. Cotton | This work is licensed under CC Attribution 4.0
Submitted: 24 June 2019 | Published: 23 March 2009

About the author(s)

S. Innes, KID-CRU (Children's Infectious Diseases Clinical Research Unit), Tygerberg Academic Hospital, Tygerberg, W Cape, South Africa
H. S. Schaaf, Department of Paediatrics and Child Health, Tygerberg Academic Hospital and Stellenbosch University, Tygerberg, South Africa
M. F. Cotton, KID-CRU (Children's Infectious Diseases Clinical Research Unit), Tygerberg Academic Hospital, Tygerberg, W Cape; Department of Paediatrics and Child Health, Tygerberg Academic Hospital and Stellenbosch University, Tygerberg, South Africa

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Abstract

Tuberculosis immune reconstitution inflammatory syndrome (IRIS) may present as new or worsening cavitation. We present an HIV-infected infant in whom TB infection and subsequent cavitation of the Ghon focus appeared to coincide with immune reconstitution due to highly active antiretroviral therapy (HAART). TB-IRIS in response to infection that occurs after starting HAART has not previously been described.

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Crossref Citations

1. Side Effects of the Immune System: Lessons from Tuberculosis-Related Immune Reconstitution Inflammatory Syndrome
D. Buonsenso, T. Pirronti, O. Genovese, L. Gargiullo, O. Ranno, P. Valentini
European Journal of Inflammation  vol: 10  issue: 1  first page: 1  year: 2012  
doi: 10.1177/1721727X1201000101