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Tuberculosis prevention in HIV-infected pregnant women in South Africa

C E Martin, V Black
Southern African Journal of HIV Medicine | Vol 13, No 4 | a113 | DOI: https://doi.org/10.4102/sajhivmed.v13i4.113 | © 2012 C E Martin, V Black | This work is licensed under CC Attribution 4.0
Submitted: 15 December 2012 | Published: 04 October 2012

About the author(s)

C E Martin, WITS Reproductive Health and HIV Institute, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
V Black, WITS Reproductive Health and HIV Institute, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

Abstract

The high burden of HIV and tuberculosis (TB) among pregnant women in South Africa contributes to a high maternal mortality rate. Isoniazid preventive therapy (IPT) is recommended for the prevention of active TB in HIV-infected individuals, including pregnant women. However, there are few data regarding IPT use in the latter, with concern regarding the concurrent use of IPT with nevirapine in pregnancy, as both treatments are hepatotoxic. The benefit and safety of IPT in HIV-infected pregnant women has not been established. We recommend a simplification of HIV and TB interventions by providing triple antiretroviral therapy to all HIV-infected pregnant women.

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