Guideline

SAHCS Guideline for the prevention, diagnosis and management of cryptococcal disease among persons living with HIV: Update to induction treatment for cryptococcal meningitis

Nelesh P. Govender, Graeme Meintjes, Jonathan Falconer, Kyla Murphy, Jeremy Nel, Helena Rabie, Lisa Frigati, Denasha L. Reddy, Halima Dawood, Ebrahim Variava, Samantha Potgieter, Tom Boyles, Sarah L. Stacey, Petho Mangena, Matamela C. Madua, Camilla Wattrus, Mahomed-Yunus S. Moosa
Southern African Journal of HIV Medicine | Vol 27, No 1 | a1789 | DOI: https://doi.org/10.4102/sajhivmed.v27i1.1789 | © 2026 Nelesh P. Govender, Graeme Meintjes, Jonathan Falconer, Kyla Murphy, Jeremy Nel, Helena Rabie, Lisa Frigati, Denasha L. Reddy, Halima Dawood, Ebrahim Variava, Samantha Potgieter, Tom Boyles, Sarah L. Stacey, Petho Mangena, Matamela C. Madua, Camilla Wattr | This work is licensed under CC Attribution 4.0
Submitted: 05 November 2025 | Published: 18 March 2026

About the author(s)

Nelesh P. Govender, Wits Mycology Division, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; and, Institute for Infection and Immunity, City St. George’s University of London, London, United Kingdom; and, MRC Centre for Medical Mycology, University of Exeter, Exeter, United Kingdom
Graeme Meintjes, Blizard Institute, Queen Mary University of London, London, United Kingdom; and, Department of Medicine and Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
Jonathan Falconer, Division of Infectious Diseases, Department of Medicine, School of Clinical Medicine, University of the Witwatersrand, Johannesburg, South Africa; and, Division of Clinical Microbiology, Department of Medicine, School of Clinical Medicine, University of the Witwatersrand, Johannesburg, South Africa
Kyla Murphy, Wits Mycology Division, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; and, Department of Medicine, University of Cape Town, Cape Town, South Africa; and, Neuroscience Institute, University of Cape Town, Cape Town, South Africa
Jeremy Nel, Division of Infectious Diseases, Department of Medicine, School of Clinical Medicine, University of the Witwatersrand, Johannesburg, South Africa
Helena Rabie, Department of Paediatrics, Stellenbosch University, Stellenbosch, South Africa; and, Department of Paediatrics, Tygerberg Hospital, Cape Town, South Africa
Lisa Frigati, Department of Paediatrics, Stellenbosch University, Stellenbosch, South Africa; and, Department of Paediatrics, Tygerberg Hospital, Cape Town, South Africa
Denasha L. Reddy, Division of Infectious Diseases, Department of Medicine, School of Clinical Medicine, University of the Witwatersrand, Johannesburg, South Africa; and, Vaccines and Infectious Diseases Analytics Research Unit (Wits-Vida), University of the Witwatersrand, Johannesburg, South Africa
Halima Dawood, Infectious Disease Unit, Greys Hospital, Pietermaritzburg, South Africa; and, Centre for the AIDS Programme of Research in South Africa, (CAPRISA), University of KwaZulu-Natal, Durban, South Africa
Ebrahim Variava, Department of Internal Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; and, Klerksdorp Tshepong Hospital Complex, Klerksdorp, South Africa; and, Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa
Samantha Potgieter, Department of Internal Medicine, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa
Tom Boyles, Clinical HIV Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
Sarah L. Stacey, Division of Infectious Diseases, Department of Medicine, School of Clinical Medicine, University of the Witwatersrand, Johannesburg, South Africa; and, Department of Medicine, Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg, South Africa
Petho Mangena, Department of Medicine, Polokwane Hospital, Polokwane, South Africa
Matamela C. Madua, Department of Cardiology, Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg, South Africa
Camilla Wattrus, Southern African HIV Clinicians Society (SAHCS), Johannesburg, South Africa
Mahomed-Yunus S. Moosa, Department of Infectious Disease, Division of Internal Medicine, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa

Abstract

No abstract available.

Keywords

cryptococcal disease; cryptococcal meningitis; cryptococcal; induction treatment

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