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Original Research
Abacavir: it’s use and hypersensitivity
Southern African Journal of HIV Medicine | Vol 10, No 4 | a265 |
DOI: https://doi.org/10.4102/sajhivmed.v10i4.265
| © 2009 Helena Rabie, Kristin Lorenc Henning, Pierre Schoeman, Nico de Villiers, G HJ Pretorius, Mark F Cotton
| This work is licensed under CC Attribution 4.0
Submitted: 15 December 2009 | Published: 14 December 2009
Submitted: 15 December 2009 | Published: 14 December 2009
About the author(s)
Helena Rabie,Kristin Lorenc Henning, Department of Paediatrics and Child Health
Pierre Schoeman, PathCare Laboratories, N1 City, Goodwood
Nico de Villiers, PathCare Laboratories, N1 City, Goodwood
G HJ Pretorius,
Mark F Cotton,
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Abacavir, a nucleoside reverse transcriptase inhibitor, is useful in first and second line therapy as well as a substitute for Stavudine and Zidovudine for toxicity. Although safe and well tolerated, a life threatening hypersensitivity reaction can occur. The risk for developing this reaction relates to the presence of specific genotypes especially HLA-B*5701.
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