Original Research

Abacavir: it’s use and hypersensitivity

Helena Rabie, Kristin Lorenc Henning, Pierre Schoeman, Nico de Villiers, G HJ Pretorius, Mark F Cotton
Southern African Journal of HIV Medicine | Vol 10, No 4 | a265 | DOI: https://doi.org/10.4102/sajhivmed.v10i4.265 | © 2009 Helena Rabie, Kristin Lorenc Henning, Pierre Schoeman, Nico de Villiers, G HJ Pretorius, Mark F Cotton | This work is licensed under CC Attribution 4.0
Submitted: 15 December 2009 | Published: 14 December 2009

About the author(s)

Helena Rabie,
Kristin Lorenc Henning, Department of Paediatrics and Child Health
Pierre Schoeman, PathCare Laboratories, N1 City, Goodwood
Nico de Villiers, PathCare Laboratories, N1 City, Goodwood
G HJ Pretorius,
Mark F Cotton,

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Abstract

Abacavir, a nucleoside reverse transcriptase inhibitor, is useful in first and second line therapy as well as a substitute for Stavudine and Zidovudine for toxicity. Although safe and well tolerated, a life threatening hypersensitivity reaction can occur. The risk for developing this reaction relates to the presence of specific genotypes especially HLA-B*5701.

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