Case Report

Neuroendocrine tumour in a patient with neurofibromatosis type 1 and HIV

Juliane Hiesgen, Ebrahim Variava
Southern African Journal of HIV Medicine | Vol 16, No 1 | a323 | DOI: | © 2015 Juliane Hiesgen, Ebrahim Variava | This work is licensed under CC Attribution 4.0
Submitted: 05 January 2015 | Published: 26 June 2015

About the author(s)

Juliane Hiesgen, Department of Neurology, Kalafong Hospital, University of Pretoria, South Africa
Ebrahim Variava, Department of Internal Medicine, Tshepong Hospital, University of the Witwatersrand


We report the case of an HIV-positive female patient with neurofibromatosis type 1 who wastreated for recurrent peptic ulcer disease and later developed diabetes mellitus and chronicdiarrhoea. A metastasising somatostatinoma was histologically proven and evidence of aconcomitant gastrin-producing neuroendocrine tumour was found. Neuroendocrine tumours (NETs) are very rare neoplasms originating from a wide variety of endocrine and nervoussystem tissue with the ability to produce different hormones. A somatostatin- and gastrinsecreting NET in a patient with HIV has not been reported in the literature, to the best ofour knowledge. We discuss oncogenic pathomechanisms related to the underlying conditionsand propose stringent monitoring for tumours in HIV-positive patients with phakomatoses aswell as initiation of antiretroviral therapy.


Phakomatoses; HIV; malignancies


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