Review Article

Recommendations for the management of indeterminate HIV PCR results within South Africa’s early infant diagnosis programme

Ahmad Haeri Mazanderani, Karl-Günter Technau, Nei-yuan Hsiao, Jean Maritz, Sergio Carmona, Gayle G. Sherman
Southern African Journal of HIV Medicine | Vol 17, No 1 | a451 | DOI: https://doi.org/10.4102/sajhivmed.v17i1.451 | © 2016 Ahmad Haeri Mazanderani, Karl-Günter Technau, Nei-yuan Hsiao, Jean Maritz, Sergio Carmona, Gayle G. Sherman | This work is licensed under CC Attribution 4.0
Submitted: 17 November 2015 | Published: 13 May 2016

About the author(s)

Ahmad Haeri Mazanderani, Centre for HIV & STIs, National Institute for Communicable Diseases; Department of Medical Virology, University of Pretoria, South Africa
Karl-Günter Technau, Empilweni Services and Research Unit, Johannesburg; Department of Paediatrics and Child Health, University of the Witwatersrand, South Africa
Nei-yuan Hsiao, Division of Medical Virology, University of Cape Town; National Health Laboratory Service, South Africa
Jean Maritz, National Health Laboratory Service; Division of Medical Virology, Department of Pathology, Stellenbosch University, South Africa, South Africa
Sergio Carmona, National Health Laboratory Service; Department of Molecular Medicine and Haematology, University of the Witwatersrand, South Africa
Gayle G. Sherman, Centre for HIV & STIs, National Institute for Communicable Diseases; Department of Paediatrics and Child Health, University of the Witwatersrand, South Africa


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Abstract

Indeterminate HIV PCR results represent missed diagnostic opportunities within South Africa's early infant diagnosis (EID) programme. These results not only delay diagnosis and appropriate management but are also a source of confusion and apprehension amongst clinicians and caregivers. We describe the extent of indeterminate HIV PCR results within South Africa's EID programme and provide recommendations for the management of these cases, both in terms of laboratory practice and the clinical care of the infants.

Keywords: EID; HIV PCR; Indeterminate


Keywords

EID; HIV PCR; Indeterminate

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Crossref Citations

1. Interpretation of indeterminate HIV-1 PCR results are influenced by changing vertical transmission prevention regimens
Jean Maritz, Jayshree Narvin Maharaj, Mark Frederic Cotton, Wolfgang Preiser
Journal of Clinical Virology  vol: 95  first page: 86  year: 2017  
doi: 10.1016/j.jcv.2017.08.013