Case Report

The end of the line? A case of drug resistance to third-line antiretroviral therapy

Theresa M. Rossouw, Sonia Hitchcock, Mariëtte Botes
Southern African Journal of HIV Medicine | Vol 17, No 1 | a454 | DOI: | © 2016 Theresa M. Rossouw, Sonia Hitchcock, Mariëtte Botes | This work is licensed under CC Attribution 4.0
Submitted: 09 December 2015 | Published: 31 May 2016

About the author(s)

Theresa M. Rossouw, Department of Immunology, University of Pretoria, South Africa
Sonia Hitchcock, Department of Family Medicine, University of Pretoria, South Africa; Kalafong Provincial Tertiary Hospital, South Africa
Mariëtte Botes, Muelmed Hospital, Pretoria, South Africa


HIV drug resistance has been described in all antiretroviral drug classes and threatens the long-term success of HIV treatment. Here, we describe the first reported case of acquired resistance to the integrase strand transfer inhibitors in South Africa. This case illustrates the dilemma of treatment in the context of inadequate adherence and poor psychosocial support and highlights the potential risk of transmission of multidrug-resistant virus.

Keywords: HIV drug resistance; third line



HIV drug resistance; third line


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Crossref Citations

1. Analyses of HIV-1 integrase sequences prior to South African national HIV-treatment program and availability of integrase inhibitors in Cape Town, South Africa
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