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Case Report
The end of the line? A case of drug resistance to third-line antiretroviral therapy
Submitted: 09 December 2015 | Published: 31 May 2016
About the author(s)
Theresa M. Rossouw, Department of Immunology, University of Pretoria, South AfricaSonia Hitchcock, Department of Family Medicine, University of Pretoria, South Africa; Kalafong Provincial Tertiary Hospital, South Africa
Mariëtte Botes, Muelmed Hospital, Pretoria, South Africa
Abstract
HIV drug resistance has been described in all antiretroviral drug classes and threatens the long-term success of HIV treatment. Here, we describe the first reported case of acquired resistance to the integrase strand transfer inhibitors in South Africa. This case illustrates the dilemma of treatment in the context of inadequate adherence and poor psychosocial support and highlights the potential risk of transmission of multidrug-resistant virus.
Keywords: HIV drug resistance; third line
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