Review Article

Human papillomavirus infection and disease in men: Impact of HIV

Sinead Delany-Moretlwe, A Chikandiwa, J Gibbs
Southern African Journal of HIV Medicine | Vol 14, No 4 | a55 | DOI: https://doi.org/10.4102/sajhivmed.v14i4.55 | © 2013 Sinead Delany-Moretlwe, A Chikandiwa, J Gibbs | This work is licensed under CC Attribution 4.0
Submitted: 12 December 2013 | Published: 22 November 2013

About the author(s)

Sinead Delany-Moretlwe, Wits Reproductive Health and HIV Institute, University of the Witwatersrand, Johannesburg, South Africa, South Africa
A Chikandiwa, Wits Reproductive Health and HIV Institute, University of the Witwatersrand, Johannesburg, South Africa
J Gibbs, Wits Reproductive Health and HIV Institute, University of the Witwatersrand, Johannesburg, South Africa; London School of Hygiene and Tropical Medicine, London, United Kingdom

Abstract

There is growing evidence of a significant burden of human papillomavirus (HPV) infection and associated disease in men. High rates of HPV infection have been observed in men from sub-Saharan Africa where HIV prevalence is high. HIV infection increases HPV prevalence, incidence and persistence and is strongly associated with the development of anogenital warts and anal, penile and head and neck cancers in men. Despite increasing access to antiretroviral therapy, there appears to be little benefit in preventing the development of these cancers in HIV-positive men, making prevention of infection a priority. New prevention options that are being introduced in many African countries include male circumcision and HPV vaccination. However, more data are needed on the burden of HPV disease in men before boys are included in HPV vaccination programmes.


Keywords

HPV; human papillomavirus; HIV; men

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