Case Report

Native valve endocarditis due to Candida parapsilosis in an adult patient

Krishnee Moodley, Chetna Narsai Govind, Abdool Kader Cassim Peer, Shabbir Dawood, Mohamed Hanif Hassim, Julian Deonarain
Southern African Journal of HIV Medicine | Vol 14, No 3 | a68 | DOI: https://doi.org/10.4102/sajhivmed.v14i3.68 | © 2013 Krishnee Moodley, Chetna Narsai Govind, Abdool Kader Cassim Peer, Shabbir Dawood, Mohamed Hanif Hassim, Julian Deonarain | This work is licensed under CC Attribution 4.0
Submitted: 12 December 2013 | Published: 17 September 2013

About the author(s)

Krishnee Moodley, Lancet Laboratories, KwaZulu-Natal, South Africa, South Africa
Chetna Narsai Govind, Lancet Laboratories, KwaZulu-Natal, South Africa, South Africa
Abdool Kader Cassim Peer, Lancet Laboratories, KwaZulu-Natal, South Africa, South Africa
Shabbir Dawood, Lancet Laboratories, KwaZulu-Natal, South Africa, South Africa
Mohamed Hanif Hassim, Lancet Laboratories, KwaZulu-Natal, South Africa, South Africa
Julian Deonarain, Lancet Laboratories, KwaZulu-Natal, South Africa, South Africa


Share this article

Bookmark and Share

Abstract

Candida endocarditis is rare, but associated with a high mortality. The most common species implicated is Candida albicans. The epidemiology of invasive Candida infections is changing, with a predominance of non-albicans species causing invasive disease. We describe a case of Candida parapsilosis endocarditis in an HIV-positive patient with pre-existing mitral valve disease and renal failure on haemodialysis. The patient presented with fever and malaise. Clinical examination revealed pulmonary oedema and severe mitral regurgitation. Blood cultures were positive for C. parapsilosis. β-D-glucan assay levels were elevated. An echocardiogram showed large, friable vegetations on the mitral valve. C. parapsilosis was cultured from the haemodialysis tip and the vegetations. The patient responded well to mitral valve replacement and antifungal therapy. A high index of suspicion and aggressive diagnostic modalities and therapy are essential in patients with candidaemia, to decrease mortality due to this condition.


Keywords

HIV; Candida parapsilosis; candida endocarditis; beta-d-glucan assay

Metrics

Total abstract views: 1447
Total article views: 2768

 

Crossref Citations

1. Candida parapsilosis endocarditis in an intravenous drug abuser: an autopsy report
Manoj Gopal Madakshira, Amanjit Bal, ShivaPrakash, Manish Rathi, Rajesh Vijayvergiya
Cardiovascular Pathology  vol: 36  first page: 30  year: 2018  
doi: 10.1016/j.carpath.2018.05.005