Guideline for the prevention, diagnosis and management of cryptococcal meningitis among HIV-infected persons: 2013 update

The Southern African HIV Clinicians Society
Southern African Journal of HIV Medicine | Vol 14, No 2 | a82 | DOI: | © 2013 The Southern African HIV Clinicians Society | This work is licensed under CC Attribution 4.0
Submitted: 12 December 2013 | Published: 04 June 2013

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The Southern African HIV Clinicians Society, SAHIVSOC, Johannesburg, South Africa, South Africa

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Six years after the first Society guidelines were published, cryptococcal meningitis (CM) remains an important cause of morbidity and mortality among HIV-infected adults in South Africa. Several important developments have spurred the  publication of updated guidelines to manage this common fungal opportunistic infection. Recommendations described here include: (1) screening and pre-emptive treatment; (2) laboratory diagnosis and monitoring; (3) management of a first episode of CM; (4) amphotericin B deoxycholate toxicity prevention, monitoring and management; (5) timing of antiretroviral therapy among patients with CM; (6) management of raised intracranial pressure; (7) management of relapse episodes of CM.


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