Original Research

Ocular manifestations of people living with HIV in Tunisia

Dorsaf Saadouli, Lamia Ammari, Khaoula Ben Mansour, Yosra Yahyaoui, Sameh Aissa, El Afrit Mohamed Ali, Salem Yahyaoui, Hanene Tiouri
Southern African Journal of HIV Medicine | Vol 22, No 1 | a1193 | DOI: https://doi.org/10.4102/sajhivmed.v22i1.1193 | © 2021 Dorsaf Saadouli, Lamia Ammari, Khaoula Ben Mansour, Yosra Yahyaoui, Sameh Aissa, El Afrit Mohamed Ali, Salem Yahyaoui, Hanene Tiouri | This work is licensed under CC Attribution 4.0
Submitted: 06 November 2020 | Published: 19 March 2021

About the author(s)

Dorsaf Saadouli, Department of Ophthalmology, La Rabta Hospital, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia
Lamia Ammari, Department of Infectious Diseases, La Rabta Hospital, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia
Khaoula Ben Mansour, Department of Ophthalmology, La Rabta Hospital, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia
Yosra Yahyaoui, Faculty of Medicine of Tunis, University Tunis El Manar, Tunis, Tunisia
Sameh Aissa, Department of Infectious Diseases, La Rabta Hospital, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia
El Afrit Mohamed Ali, Department of Ophthalmology, La Rabta Hospital, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia
Salem Yahyaoui, Faculty of Medicine of Tunis, University Tunis El Manar, Tunis, Tunisia
Hanene Tiouri, Department of Infectious Diseases, La Rabta Hospital, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia


Share this article

Bookmark and Share

Abstract

Background: Ocular involvement is a common complication of human immunodeficiency virus (HIV). Knowledge about this topic in Tunisia is limited.

Objective: To investigate ophthalmic manifestations in patients living with HIV in Tunisia.

Method: This was an observational study, performed between January 2007 and December 2016. We included patients with ocular disorders related to HIV. The data were recorded retrospectively from chart review.

Results: Amongst 98 people living with HIV (PLWH), 36 participants (55 eyes) had ocular manifestations. The mean age was 32.2 ± 5.6 years. Twenty-four patients were men and 12 were women. The mean value of CD4+ T-cell count was 156.5 ± 4.2 cells/µL. Bilateral lesions were found in 19 eyes. Best corrected visual acuity was better than 6/12 in 36 eyes. The most common ocular finding was dry eye syndrome (22%), cotton-wool spots (20%) and retinal haemorrhage (16%) followed by cytomegalovirus (CMV) retinitis (9%), anterior uveitis (7%), toxoplasmosis (4%) and tuberculosis retinochoroiditis (7%) Herpetic keratitis (5%), Herpes zoster ophthalmicus (2%) and syphilitic chorioretinitis (2%). Papilledema was found in three eyes (5%). Panuveitis was observed in four eyes (7%): three of them were associated with chorioretinal toxoplasmosis, syphilitic chorioretinitis and CMV retinitis. The fourth was attributable to immune recovery uveitis. A CD4+ T-cell count of ≤ 200 cells/µL was found to be an independent risk factor for developing posterior segment manifestations.

Conclusion: Various ophthalmic manifestations were observed in PLWH. The most common lesion was retinopathy. Ocular involvement can be serious leading to poor visual prognosis, which requires close collaboration between the ophthalmologist and infectious disease physician.


Keywords

acquired immunodeficiency syndrome; human immunodeficiency virus; ocular manifestation; uveitis; immune recovery uveitis; cytomegalovirus retinitis

Metrics

Total abstract views: 767
Total article views: 534


Crossref Citations

No related citations found.