Original Research

Estimated use of abacavir among adults and children enrolled in public sector antiretroviral therapy programmes in Gauteng, South Africa

D Evans, M Maskwe, C Heneger, I Sanne
Southern African Journal of HIV Medicine | Vol 13, No 3 | a126 | DOI: https://doi.org/10.4102/sajhivmed.v13i3.126 | © 2012 D Evans, M Maskwe, C Heneger, I Sanne | This work is licensed under CC Attribution 4.0
Submitted: 15 December 2012 | Published: 16 August 2012

About the author(s)

D Evans, Health Economics and Epidemiology Research Office, Department of Medicine, University of the Witwatersrand, Johannesburg, South Africa
M Maskwe, Health Economics and Epidemiology Research Office, Department of Medicine, University of the Witwatersrand, Johannesburg, South Africa
C Heneger, Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, USA
I Sanne, Clinical HIV Research Unit, Department of Medicine, University of the Witwatersrand, and Right to Care, Johannesburg, South Africa

Abstract

In South Africa, abacavir (ABC) is currently recommended as part of first- and second-line antiretroviral therapy (ART) for HIV-positive paediatric patients. Concerns about overprescribing of the drug, particularly to adults, led to an analysis of ABC use in public sector ART programmes. We investigated current prescription of the drug to adults and children accessing ART in 4 public sector programmes across Gauteng Province, South Africa. ABC was almost exclusively prescribed to children initiating ART and adults requiring regimen changes due to drug toxicities. Patterns of ABC use among HIV-positive paediatric patients followed national ART treatment guidelines on the application of the drug. Although ABC is commonly used in the private sector for adults, the current national ART treatment guidelines for adults and adolescents should include ABC as an alternative to standard first- or second-line ART.

Keywords

HIV; ART; Abacavir; public sector;

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Crossref Citations

1. Adverse Drug Reactions Among Patients Initiating Second-Line Antiretroviral Therapy in South Africa
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Drug Safety  vol: 41  issue: 12  first page: 1343  year: 2018  
doi: 10.1007/s40264-018-0698-3