Case Report

Breaking the unbreakable: A paediatric case of dolutegravir resistance from KwaZulu-Natal

Sibongiseni Malinga, Aabida Khan, Moherndran Archary
Southern African Journal of HIV Medicine | Vol 24, No 1 | a1458 | DOI: https://doi.org/10.4102/sajhivmed.v24i1.1458 | © 2023 Sibongiseni Malinga, Aabida Khan, Moherndran Archary | This work is licensed under CC Attribution 4.0
Submitted: 22 September 2022 | Published: 23 May 2023

About the author(s)

Sibongiseni Malinga, Department of Paediatrics, King Edward VIII Hospital, Durban, South Africa
Aabida Khan, Department of Virology, Inkosi Albert Luthuli Central Hospital, National Health Laboratory Service (NHLS), Durban, South Africa; and, School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa
Moherndran Archary, Department of Paediatrics, King Edward VIII Hospital, Durban, South Africa; and, Department of Paediatrics and Child Health, Faculty of Health Sciences, University of KwaZulu-Natal, Durban, South Africa

Abstract

We report a case of dolutegravir resistance in KwaZulu-Natal in a 13-year-old male two years after starting dolutegravir. Resistance most likely developed due to poor adherence as a result of psychosocial issues. This case highlights the importance of the role of the family unit in impacting adherence and close monitoring of treatment-experienced patients with virologic failure following switching to dolutegravir-based regimens.


Keywords

paediatrics; dolutegravir; DTG; resistance; HIV; adolescence

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