Case Report

Gestational trophoblastic neoplasm and women living with HIV and/or AIDS

Pieter Barnardt, Martha Relling
Southern African Journal of HIV Medicine | Vol 16, No 1 | a344 | DOI: https://doi.org/10.4102/sajhivmed.v16i1.344 | © 2015 Pieter Barnardt, Martha Relling | This work is licensed under CC Attribution 4.0
Submitted: 09 January 2015 | Published: 03 July 2015

About the author(s)

Pieter Barnardt, Department of Medical Imaging and Clinical Oncology, Division of Radiation Oncology, University of Stellenbosch, Tygerberg Campus, South Africa
Martha Relling, Department of Medical Imaging and Clinical Oncology, Division of Radiation Oncology, University of Stellenbosch, Tygerberg Campus, South Africa


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Abstract

The 2011 World Health Organization global report on HIV and/or AIDS estimated that sub-Saharan Africa comprised 67% of the global HIV burden, with a current estimate of 5.9 million cases in South Africa. Since the introduction of antiretroviral therapy, there has been an increase in the incidence of non-AIDS-defining cancers. Gestational trophoblastic neoplasm (GTN) is a rare pregnancy-related disorder with an incidence ranging from 0.12–0.7/1000 pregnancies in Western nations. The overall cure rate is about 90%. Response to treatment for GTN is generally favourable; but the sequelae of HIV and/or AIDS, the resultant low CD4 counts, comorbidities, poor performance status and the extent of metastatic disease in patients receiving chemotherapy, compromise the prognosis and survival.


Keywords

Gestational Trophoblastic Neoplasm (GTN), HIV/AIDS, Choriocarcinoma, Chemotherapy

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