Guideline

Guideline on the management of occupational and non-occupational exposure to the human immunodeficiency virus and recommendations for post-exposure prophylaxis: 2015 Update

Michelle Moorhouse, Linda G. Bekker, Vivian Black, Francesca Conradie, Beth Harley, Pauline Howell, Gary Maartens, Tari Papavarnavas, Kevin Rebe, Gillian Sorour, Francois Venter, Carole L. Wallis
Southern African Journal of HIV Medicine | Vol 16, No 1 | a399 | DOI: https://doi.org/10.4102/sajhivmed.v16i1.399 | © 2015 Michelle Moorhouse, Linda G. Bekker, Vivian Black, Francesca Conradie, Beth Harley, Pauline Howell, Gary Maartens, Tari Papavarnavas, Kevin Rebe, Gillian Sorour, Francois Venter, Carole L. Wallis | This work is licensed under CC Attribution 4.0
Submitted: 19 June 2015 | Published: 10 November 2015

About the author(s)

Michelle Moorhouse, Wits Reproductive Health and HIV Institute, Johannesburg, South Africa
Linda G. Bekker, The Desmond Tutu HIV Centre, University of Cape Town, South Africa
Vivian Black, Wits Reproductive Health and HIV Institute, Johannesburg, South Africa
Francesca Conradie, Right to Care and Clinical HIV Research Unit, University of Witwatersrand, South Africa
Beth Harley, City Health, City of Cape Town, South Africa
Pauline Howell, Wits Health Consortium, University of Witwatersrand, South Africa
Gary Maartens, Department of Medicine, University of Cape Town, South Africa
Tari Papavarnavas, Helen Joseph Hospital, Right to Care, South Africa
Kevin Rebe, Anova Health Institute, Johannesburg, South Africa
Gillian Sorour, Gauteng Department of Health, Gauteng, South Africa; President’s Emergency Plan for AIDS Relief, Wits Reproductive Health & HIV Institute, South Africa
Francois Venter, Wits Reproductive Health and HIV Institute, Johannesburg, South Africa
Carole L. Wallis, BARC, Johannesburg, South Africa; Lancet Laboratories, Johannesburg, South Africa


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Abstract

This guideline is an update of the post-exposure prophylaxis (PEP) guideline published by the Southern African HIV Clinicians Society in 2008. It updates the recommendations on the use of antiretroviral medications to prevent individuals who have been exposed to a potential HIV source, via either occupational or non-occupational exposure, from becoming infected with HIV. No distinction is made between occupational or non-occupational exposure, and the guideline promotes the provision of PEP with three antiretroviral drugs if the exposure confers a significant transmission risk. The present guideline aligns with the principles of the World Health Organization PEP guidelines (2014), promoting simplification and adherence support to individuals receiving PEP.

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