About the Author(s)


Sabina M. Govere Email symbol
College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa

Moses J. Chimbari symbol
College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa

Citation


Govere SM, Chimbari MJ. The evolution and adoption of World Health Organization policy guidelines on antiretroviral therapy initiation in sub-Saharan Africa: A scoping review. S Afr J HIV Med. 2020;21(1), a1103. https://doi.org/10.4102/sajhivmed.v21i1.1103

Review Article

The evolution and adoption of World Health Organization policy guidelines on antiretroviral therapy initiation in sub-Saharan Africa: A scoping review

Sabina M. Govere, Moses J. Chimbari

Received: 06 May 2020; Accepted: 26 July 2020; Published: 30 Sept. 2020

Copyright: © 2020. The Author(s). Licensee: AOSIS.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background: Despite past and present global interventions, the human immunodeficiency virus (HIV) pandemic remains a public health problem in low- and middle-income countries (LMICs). The World Health Organization (WHO) has assisted these countries by providing antiretroviral therapy (ART) policies for adoption and adaptation to local needs.

Objectives: This article describes the response of countries in sub-Saharan Africa (SSA), to the WHO’s changing CD4-threshold ART-initiation recommendations of the past two decades.

Methods: Relevant articles published in international peer-reviewed journals were accessed via the following search engines: PubMed, Google Scholar, Cochrane, Embase and EBSCOhost. The study’s inclusion criteria were articles published in the English language between 2000 and 2019 that highlighted changes to the CD4 ART-initiation threshold and that focused on the WHO’s ‘commencement of ART’ policy guidelines. Sixteen studies (n = 16) from SSA were identified and included in this review: four are cross-sectional, four deal with cost-effectiveness, four are retrospective, one is a randomised trial and three are observational studies. Only studies conducted in SSA were assessed.

Results: Four themes emerged: (1) adoption of the WHO CD4-ART-initiation policy by SSA countries, (2) timely implementation of the changing guideline initiation policy in the region, (3) barriers and facilitators encountered in the implementation of the changing guidelines and (4) description of similarities in policy implementation at country level from 2002 to 2019. Regional studies – cross-sectional, observational, retrospective, cost-effectiveness and randomised have described greater access to ART in SSA. However, barriers remain. The most common barriers to the timely implementation of ‘new’ ART-initiation guidelines were economic constraints, drug stock-outs, delays in obtaining baseline blood-test results and staff shortages.

Conclusion: Although countries in SSA have adopted the WHO-ART-CD4 initiation-threshold policy guidelines, implementation has seldom occurred in a timely manner. Barriers have been identified. Whilst a small number of countries have implemented recommendations promptly, for many, the barriers still require to be overcome.

Keywords: ART initiation; WHO-ART guidelines adoption; implementation of ART guidelines in sub-Saharan Africa; CD4; human immunodeficiency virus.

Background

The first cases of the acquired immunodeficiency syndrome (AIDS) were reported in 1981. Since then, infection with human immunodeficiency virus (HIV) has spread globally and caused an estimated 74.9 million infections and 32 million AIDS-related illnesses.1 In its first 15 years no treatment could control the infection or halt its spread.2 By 2018, the African region was home to approximately 25.7 million people living with HIV (PLWH)1 and in that year alone, Africa experienced approximately 1.1 million new infections.1 Almost two-thirds of all new global infections occur in sub-Saharan Africa (SSA).1

The World Health Organization’s (WHO’s) antiretroviral therapy (ART) initiation-guidelines have changed substantially over the last two decades.2 The guidelines were first published in 2002.3 These (2002/2003) recommended starting ART in those with AIDS-related conditions and/or at a CD4 of ≤ 200 cells/mm. The available treatment at that time was expensive and toxic. Delaying ART until the CD4 reached levels < 200 c/mm3 was intended to minimise these drawbacks.4 Continued deaths from AIDS and success with ART prompted a CD4 increase in 2006 200 to 350 cells/mm3. In addition, all pregnant women and persons with Stage 3 and 4 infection were offered ART.3 In 2010, the threshold was raised to CD4 < 350 c/mm3 for all irrespective of clinical stage.4,5 By June 2013, the threshold was further increased to CD4 < 500/cells/mm3 for all children > 5 years and adults irrespective of stage/symptoms.6 In 2015, the WHO and numerous international organisations removed the CD4 threshold and recommended ART to all regardless of CD4 cell count and clinical stage.7 Data from two highly influential randomised controlled clinical trials, the START and TEMPRANO studies, underpinned this decision. Both demonstrated survival advantage to those on ART irrespective of clinical stage or CD4 count.8,9 This led to the introduction by all international agencies, including the WHO, of the policy of ‘universal test and treat (UTT)’. The WHO estimates that if these recommendations are adopted globally, 21 million deaths and 28 million new infections could be prevented by 2030.10

The rate at which countries have aligned their national ART programmes and implemented WHO guidelines since 2002 has varied. Most SSA countries took ± 2 years to implement the WHO’s 2010 ART guidelines.5 From December 2015 to May 2017, Rwanda, Kenya, Uganda, Botswana, Malawi, Zimbabwe and South Africa revised national ART eligibility guidelines to align with the WHO’s 2015 guidelines.11 On average, this integration took 12 months (range, 6–23 months).11 The implementation of the WHO guidelines in resource-constrained countries is complex. Consequently, it has not always been possible to implement the guidelines timeously where ART is most needed and where access to health services is limited.2 In this review, we sought to determine how different SSA countries adapted to the WHO’s ART-initiating CD4-threshold changes over time and how WHO guidelines have impacted ART in the region.

Methods

Search strategy and selection criteria

We carried out a systematic electronic literature search on PubMed, Google Scholar, Cochrane, Embase and EBSCO host for the period, 2000–2019 (Figure 1). The databases were selected based on our inclusion criteria and the availability of free full-text articles and papers. In this review, we used the preferred reporting items for systematic reviews and meta-analysis (PRISMA) as described by Moher et al., to identify an evidence-based dataset and to provide transparency in the selection process of the articles.12

FIGURE 1: Preferred reporting items for systematic reviews and meta-analysis flow diagram showing the process of selecting articles included in the review.

The search was based on the combination of the following terms and Boolean operators: WHO-ART guidelines or ART-initiation guidelines and changes in CD4-initiation guidelines and implementation of WHO guidelines or adoption of WHO-ART guidelines. We also applied a manual country filter to limit our search to SSA. Articles published in a language other than English and articles focusing on ART regimen-change were excluded. The study included articles that focused on CD4-threshold changes and were published between 2000 and 2019. The following articles were not included: duplicates, articles not centered on the WHO and ART initiation guidelines or their adoption and implementation. Exclusion was based on the screening of the title and abstract.

The search process is illustrated in Figure 1. Seventy-nine (79) duplicate articles were removed, which were identical in Google Scholar and PubMed. Fewer articles dealt with the topic in Cochrane and Embase. The articles in PubMed were more detailed, easier to search and free to access. We also excluded 187 articles because they did not specifically address implementation based on CD4-threshold changes. Another 11 were excluded because they focused on only regimen change. Only 16 articles remained. These covered quantitative and qualitative synthesis of how SSA countries adopted the WHO and ART initiation guidelines between 2000 and 2019 and its impact on the management of HIV.

Data extraction and synthesis

The following information was extracted from selected studies using a template: publication details, country of study, objective(s) of the study, study design, summary of findings and theme (Table 1). Two review authors independently assessed the eligibility of the studies identified in the search. Articles with different study designs and objectives were selected to reduce the risk of bias. We used different high-impact databases to search for articles and global authors. The study designs were divided into five groups: cross sectional, cost-effectiveness, retrospective, randomised trial and observational studies. We did not subject the reviewed articles to this quality process because this is a scoping review. For synthesis, extracted information was grouped into themes derived from the articles in line with the review objectives and different study designs. The themes identified were: how different SSA countries adopted WHO and ART initiation policy guidelines at country level, timely implementation levels of the policies by different SSA countries, the barriers and facilitators to WHO and ART initiation policy adoption in SSA and the similarities in country characteristics in policy implementation in different SSA countries.

TABLE 1: Summary of studies.
TABLE 1 (Continues...): Summary of studies.
TABLE 1 (Continues...): Summary of studies.
TABLE 1 (Continues...): Summary of studies.
TABLE 1 (Continues...): Summary of studies.
Ethical consideration

Ethical approval was obtained from the University of KwaZulu-Natal Biomedical Research Ethics Committee (UKZN BREC, reference number: BREC/00000819/2019).

Results

Overview of selected studies

We reviewed 16 studies from an initial collection of 293 articles in Google Scholar, PubMed, Cochrane, Embase and EBSCOhost (Figure 1). We only reviewed studies that examined how different SSA countries adopted changes in WHO and ART initiation guidelines based on CD4 threshold and how the guidelines have impacted ART programmes in SSA. The following four themes were identified from the 16 papers: (1) Adoption of WHO and ART initiation policy guidelines at country level in SSA, (2) timely implementation of WHO and ART initiation policy guidelines at country level, (3) barriers and facilitators to WHO policy implementation in SSA and (4) characteristics at country level.

Of the 16 reviewed articles 4 (articles 4, 13, 14 and 16) addressed all 4 themes, 8 articles addressed 3 themes (articles 1, 2, 7, 9, 10, 11, 12 and 15) and 4 articles (articles 2, 5, 6 and 8) addressed only 2 themes. The theme of the adoption of the WHO-ART initiation guidelines at country level was dominant in all articles.

Theme 1: Adoption of World Health Organization antiretroviral therapy initiation policy guidelines at country level in sub-Saharan Africa

The results confirm that all the countries in SSA that are part of this review have adopted the WHO and ART initiation guidelines since 2002. Hsieh et al. reported that between July 2013 and July 2015, seven national policy documents incorporating the 2013 WHO guidelines were developed in Kenya, Malawi, Tanzania, Uganda, Zimbabwe and two in South Africa.6 This was further supported by Ross et al. who found that SSA countries had some national explicit policies that targeted increasing ART access in line with the WHO 2013 guidelines on ART.19 In his study, Hsieh et al. indicated that community consultations are crucial if policies are to be effectively implemented.6 Labhardt et al. found that health centres in Lesotho took longer to adopt the new guidelines because of limited knowledge of WHO policy changes.21

Rwanda implemented the 2006, 2010, 2013 and 2015 WHO and ART initiation guidelines in a timely manner, that is, on an average within 6 months of international release.25 Part of Rwanda’s success is attributed to the cooperation of government and non-governmental service providers.

Theme 2: The timely implementation of World Health Organization antiretroviral therapy initiation policy guidelines at country level

Teasdale et al. describe high rates of early – within 3 months – ART initiation amongst ART-eligible Rwandan patients. Indeed, by 2012, the Rwanda National HIV Care and Treatment Programme had managed to initiate 94% of eligible PLWH on ART in line with the 2006 and 2010 WHO guidelines. Rwanda was also one of the first countries in SSA to implement the higher CD4+ initiation threshold for ART eligibility.22 In an observational study in Kenya, Uganda and Zambia, Duber et al. indicate that national HIV programmes have implemented WHO 2013 guidelines at health facility level.17 These findings suggest that several countries have moved quickly to align with the WHO.

However, in a study conducted in 15 SSA countries, facilities were slow to align with the WHO’s 2006 and 2010 guidelines. They experienced delays in the actual implementation and expanding access to ART.20 Burrage et al. noted that few Tanzanians were initiated on ART at CD4 counts of ≤ 500/µL in 2015 despite the country’s earlier adoption of the 2013 WHO guidelines. As a result, only 64% of eligible PLWH were initiated on treatment.14 Stanecki et al. recorded that the number of PLWH eligible for ART in low- and middle-income countries (LMICs) under the revised 2010 WHO guidelines was 14.6 million at a time when only an estimated 10.1 million people actually received ART.20 As of 2015, all 20 SSA-supported U.S. President’s Emergency Plan for AIDS Relief (PEPFAR) countries had adopted the 2013 WHO guidelines for ART eligibility. Nevertheless, alignment and implementation with national guidelines took at least 2 years in all 20 countries.14 This demonstrates the failure of SSA countries to align and implement country guidelines timeously with the WHO.

Theme 3: Barriers to and facilitators of antiretroviral therapy initiation policy implementation

Fourteen studies examined the barriers to and facilitators of ART-initiation policy implementation in SSA. Ambia et al. reported a significant increase in ART initiations, from 42% to 87%, in some facilities in the urban centres of Kenya, Malawi, South Africa (SA), Tanzania, Uganda and Zimbabwe.13 Healthcare workers’ (HCWs) attitudes were found to be both a barrier and a facilitator of implementation at the facility level. Teasdale et al. reported that positive learning attitudes from HCWs were found to be an enabler for WHO policy adoption in Rwanda. Furthermore, the Rwandan government’s health department assembled a task team to ensure that the entire country was supported in the implementation of the revised guidelines.22 Hsieh et al. found, however, that HCWs in Malawi and Uganda were slow to implement the 2013 WHO guidelines because their communities ‘had not been consulted and hence lacked understanding’ of the guidelines.6 Similarly, Labhardt et al., in Lesotho found that HCWs especially in rural facilities, took longer to adopt and implement the 2006 and 2010 guidelines because of limited training.21 There was little support, mentoring and supervision and overall, less knowledge of health policy. The trainings were conducted in the cities. Travel from remote areas proved a challenge as facilities would have been left without clinical staff. The authors make the point that the government did not make sufficient effort to deploy trainers in the remote areas where more people needed the services.

The cost-effectiveness articles namely 8, 9, 10 and 11, in Table 1, indicate that economic constraints hindered various countries from implementing guidelines timeously. An Ethiopian study by Konings et al., revealed major financial constraints for the state even before ART services could be expanded as per the 2013 WHO guidelines. The government continued implementing the 2006 ART guidelines for more than a year after the 2010 guidelines were released because their financial capacity could not absorb the increased demand.23 Hontelez et al., in rural SA, reported that changes to the 2010 WHO guidelines led to an increase in programme costs requiring the SA government to add at least ZAR 3 billion to the healthcare budget to allow for an increase in personnel and medication.18

Most facilities in SSA failed to fully implement the policy guidelines on time because of limited ARV-stock.13 In a study from Swaziland, ARV-shortages delayed the implementation of the 2015 WHO guidelines on UTT. The available stock was not sufficient for those already on treatment.24 Walensky et al. reported that delays in obtaining baseline blood-test results delayed the SA-implementation of ART-guidelines in 2010. The 2-week turnaround time resulted in people not returning for results. Laboratory services were not readily accessible in rural areas and specimen-transport-delays resulted in the samples clotting and being discarded.5 Staff shortages in Ethiopia were identified as a barrier to implementation of the 2010 ART guidelines. In some facilities, there was neither a doctor nor a qualified nurse trained to initiate ART and PLWH had to be referred to distant hospitals.23

Theme 4: Characteristics at country level

World Health Organization guidelines are based on the best available scientific evidence and are directed to the ART-needs of LMICs. International guidelines unfortunately cannot speak to the individual economic and social realities of individual SSA countries. Of the 20 countries addressed in this review, there are nonetheless considerable similarities such as strained healthcare systems, structural and operational barriers and the need of cost-cutting measures to support healthcare systems. With the largest ART-programme on the continent, SA also carries the largest ART-related financial burden.8 Nigeria and Uganda have similar challenges.7 Funding-cuts from international donors exacerbate these challenges.12 Burrage et al. had noted that despite the expanded ART eligibility criteria, 20 PEPFAR-supported SSA countries with a high HIV-burden, had funding cuts before the release of the 2013 guidelines. This created continuing regional gaps in ART coverage.14 Drug-stock outs have been reported from Kenya, Malawi, SA, Tanzania, Uganda and Zimbabwe.13 Walsh et al. reported a similar challenge in Swaziland.24 This review has highlighted delays in aligning and implementing the WHO-ART-initiation guidelines in 20 SSA countries.14 This suggests a need for greater guidance with regard to strategy and implementation in the communities of SSA.

Discussion

This review provides detailed information regarding WHO and ART initiation guidelines on CD4 count threshold changes and adoption of the guidelines in SSA. There were some variations in study designs, however, all the articles focused on CD4 ART-initiation changes in the WHO guidelines. The findings indicate that delays in adoption and implementation were frequent and widespread throughout SSA. We employed a thematic analysis and identified four crucial themes that were in all the articles. Several barriers to implementing the guidelines were identified. These include costs related to providing ART to eligible individuals, the shortage of staff and drugs in healthcare facilities and limited training of staff when guidelines were changed.

Our findings are consistent with those of Pell et al., who reported that the implementation of the 2015 guidelines took > 12 months to be adopted in all SSA countries after their official release.1

Mikkelsen et al. noted that in an effort to contain the demand for ART, most African countries were forced to defer treatment-initiation to those eligible PLWH who were well.26 Whilst policy is well intentioned, it is informed only by epidemiological data. The state of the healthcare system and sociocultural factors are critical for controlling and ending the epidemic. Our analysis of the financial, infrastructural, human resources for health and governance landscape in SSA, the feasibility associated with costs of implementing a UTT programme indicates health systems and societal perceptions related shortcomings. Although with clinical benefits, increasing the CD4 threshold has implications that reverberate across sectors: it affects budgets, infrastructure and human resources.

The WHO-ART guidelines are crafted by an international committee of experts drawn from rich and poor nations whose mandate is to provide the world’s low- and middle-income countries (LMICs) with affordable high-quality ART guidelines. Historically, ART-guideline development in high-income countries is independent of the WHO and takes a more local character, for example, the International AIDS Society (IAS)-USA division, the Southern African HIV Clinicians Society, the European AIDS Clinical Society (EACS), the British HIV Association and the ASIA-Pacific HIV Society, etc. Liaison between the WHO and these regional societies and associations is constant. WHO guidelines committee members are also members of their national HIV-agencies. International ART guidelines are almost never produced in isolation.

Local guidelines frequently predate the release of the WHO’s guidelines as local bodies require less administration/bureaucracy and can respond to new data in real time, for example, UTT and the Insight-Start and the Temprano Studies, dolutegravir in first-line ART and the ADVANCE Trial, etc.27 Mehraj et al. noted that Canada implemented the 2002 WHO and ART guidelines 2 months before its general release.28 Canada had all the required capacity with regard to resources and regular staff trainings as well as mentoring in implementing the guidelines. Within a space of 1 month after the release of the 2015 WHO and ART initiation guidelines, 60% of the facilities in Spain were already implementing rapid ART initiation.29 This suggests that Spain had already started preparing for the changes based on EACS guidelines. Larsen et al. revealed that despite significant funding from PEPFAR, the South African National Department of Health is still failing to implement rapid ART initiation. Indeed most SSA countries have experienced fundings cuts in the past few years.30

There is a worrisome trend in SSA countries concerning the national adoption of the WHO-ART initiation guidelines. This may explain why countries in SSA are still struggling to achieve the 90-90-90 target. Despite the increase in HIV testing, rapid ART initiation based on the 2015 WHO guidelines are yet to be achieved in SSA. Furthermore, there is need for African governments to seriously consider local situations and experiences when embracing global guidelines.

Limitations

One of the limitations of our study is that we reviewed data from SSA and possibly excluded some important articles published in languages other than English. The study included only articles focusing on CD4 threshold changes on ART initiation. More articles might have been captured if language and the CD4 threshold had not been a filter.

Conclusion

We conclude that although countries in SSA have generally adopted the WHO-ART guidelines, implementation has frequently been delayed. We noted that the changes in guidelines were fraught with many challenges like switching from treating at a CD4 count of 200 cells/mm3 in 2002 to rapid ART initiation in 2015 regardless of the CD4 level. Implementation has been variable across the countries of SSA because of differences in the health systems and the availability of resources. Because of the financial burden on governments, the reduction in donor funding, the rising incidence and prevalence of HIV and sometimes and the attitudes of healthcare workers, the majority of SSA countries have experienced a delay in the implementation of the guidelines. A comprehensive approach to reduce barriers whilst enhancing facilitators may improve the situation of adopting and implementing timely ART initiation guidelines.

Acknowledgements

Competing interests

The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses or interpretation of data; in the writing of the manuscript or in the decision to publish the results.

Authors’ contributions

S.M.G. and M.J.C. conceptualised the study. S.M.G. did literature searches, analysis, writing and compilation of manuscript. M.J.C. supervised the processes, reading all versions. Both authors have read and approved the final article.

Funding information

This research was funded by the University of KwaZulu-Natal through a PhD studentship bursary awarded to SMG by the College of Health Sciences.

Data availability statement

Data sharing is not applicable to this article as no new data were created or analysed in this study.

Disclaimer

The views and opinions expressed in this article are those of the authors and do not necessarily reflect the official policy or position of any affiliated agency of the authors.

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