Guideline

Guideline for the prevention, diagnosis and management of cryptococcal meningitis among HIV-infected persons: 2013 update

The Southern African HIV Clinicians Society
Southern African Journal of HIV Medicine | Vol 14, No 2 | a82 | DOI: https://doi.org/10.4102/sajhivmed.v14i2.82 | © 2013 The Southern African HIV Clinicians Society | This work is licensed under CC Attribution 4.0
Submitted: 12 December 2013 | Published: 04 June 2013

About the author(s)

The Southern African HIV Clinicians Society, SAHIVSOC, Johannesburg, South Africa, South Africa

Abstract

Six years after the first Society guidelines were published, cryptococcal meningitis (CM) remains an important cause of morbidity and mortality among HIV-infected adults in South Africa. Several important developments have spurred the  publication of updated guidelines to manage this common fungal opportunistic infection. Recommendations described here include: (1) screening and pre-emptive treatment; (2) laboratory diagnosis and monitoring; (3) management of a first episode of CM; (4) amphotericin B deoxycholate toxicity prevention, monitoring and management; (5) timing of antiretroviral therapy among patients with CM; (6) management of raised intracranial pressure; (7) management of relapse episodes of CM.


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